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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Dehydroepiandrosterone
drug:
Serotonin
Research Papers that Mention the Interaction
“ DHEA treatment significantly reduced DA turnover (up to 33%) in the CS, but increased 5-HT turnover (up to 76%) in both regions.”
Acute dehydroepiandrosterone treatment exerts different effects on dopamine and serotonin turnover ratios in the rat corpus striatum and nucleus accumbens“ DHEA pretreatment (continued thereafter concomitantly with cocaine self-administration) attenuated cocaine-seeking behavior and elevated the levels of dopamine and serotonin in several brain regions relevant to cocaine addiction.”
“In vivo, extracellular unitary recording of 5-HT neurons performed in the dorsal raphe nucleus of these rats revealed that DHEA , 5beta-DHP and 3alpha,5alpha-THP significantly increased the firing activity of the 5-HT neurons.”
“It is hypothesized that DHEA augments the production of serotonin while d-fenfluramine enhances its release, and together these two actions may account for the synergistic action of DHEA and d-fenfluramine.”
“Thus, dehydroepiandrosterone may reduce hyperphagia by altering hypothalamic levels of serotonin.”
“The aim of this study is to emphasize by DFT calculation the possible existence of a complex between DHEA and serotonin that may have the properties of a new drug.”
Theoretical study of DHEA: comparative HF and DFT calculations of the electronic properties of a complex between DHEA and serotonin
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