Possible Interaction: Dehydroepiandrosterone and Recombinant Human Chorionic Gonadotropin

“IT ADD and IT DHEA were suppressed by 98 and 82%, respectively, by acyline and significantly increased with hCG administration.”

“In addition, long term application of HCG resulted in d) increase of 5α/5β of 11-deoxy C19 (C19O2) and 11-oxy C19 (C19O3) steroids, and e) increase of dehydroepiandrosterone.”

“Although hCG alone did not have a significant proliferative effect, hCG significantly and dose dependently stimulated MCF-7 cell growth in the presence of a submaximal concentration of DHEA (10–7 M).”

“In two different enriched populations of Leydig cells (called FI and FII) obtained from human testes (young … age 36 +/- 3 years, n = 6; aged men: mean age 73 +/- 2 years, n = 5), the dehydroepiandrosterone and testosterone in vitro outputs were increased … a dose- and time-related manners by hCG.”

“During prolonged DEX administration, hCG administration caused a slight increase in 17-hydroxypregnenolone and dehydroepiandrosterone in both the siblings, while testosterone (T) rose poorly in the brother, and estradiol did not rise at all in the sister.”

“A less striking increase in testosterone, dihydrotestosterone, dehydroepiandrosterone DHEA ), and DHEA sulfate was noted after hCG injection.”

“ hCG stimulation finally caused an increase of borderline statistical significance in testosterone, dehydroepiandrosterone , and 17-hydroxyprogesterone levels.”

“In the presence of HCG dehydroepiandrosterone production only was increased,--and this occurred in slices only.”

“ HCG treatment increased the testicular secretion of DHEA and T fivefold, Delta(4)A threefold, E(1) sixfold, and E(2) eightfold in normal men.”

“First, TGF beta 1 (1 ng/ml; 48 h) … h) were, respectively, shown to reduce and enhance dehydroepiandrosterone (DHEA) formation (evaluated in the presence of 10(-5) M WIN … HSDI) in Leydig cells when acutely (3 h) stimulated with hCG (0.01-1 ng/ml), …-hydroxycholesterol (3 micrograms/ml).”