Possible Interaction: Dehydroepiandrosterone and Progesterone

“Pregnenolone, dehydroepiandrosterone , and their sulfate esters behave as sigma1 agonists, while progesterone is a potent antagonist.”

“Our group and others have noted that when women were placed on DHEA , baseline serum progesterone levels were markedly higher than those measured prior to DHEA supplementation [2].”

“ Progesterone levels on stimulation day 5 (ng/mL) (0.58 ± 0.29 vs. 1.54 ± 0.49; p < 0.0001); and on the day of hCG administration (0.75 ± 0.31 vs. 1.87 ± 0.49; p < 0.0001) were significantly higher during DHEA treatment.”

“ Progesterone levels on stimulation day 5 (0.58 ± 0.29 ng/ml vs. 1.54 ± 0.49 ng/ml; p < 0.0001) and on the … chorionic gonadotropin administration (0.75 ± 0.31 ng/ml vs. 1.87 ± 0.49 ng/ml; p < 0.0001) were significantly higher during DHEA ….”

“However, coincubation of progesterone with (+)pentazocine, pregnenolone, or DHEA reversed their potentiating effects.”

“The increase of progesterone under DHEA supplementation in males should receive further attention.”

“The stimulation of prostaglandin F2 alpha production by the adrenal steroids was significantly reduced by the antiestrogen 4-hydroxytamoxifen at … actions on other systems) but was not affected by the antiandrogen 4-hydroxyflutamide at 10(-6) mol/L. Progesterone (… dehydroepiandrosterone (10(-6) mol/L) and … (10(-8) mol/L).”

“The number of specific progesterone binding sites was increased 3.7-, 3.2-, and 2.0-fold by delta 5-diol, DHEA , and DHEAS, respectively.”

“At the same time, high concentrations (10(-5) M) of DHA and DHAS, but not 16 alpha-OH DHA, markedly suppressed progesterone production.”

“In pregnant rats and following a 3‐week treatment with progesterone , 10 fold higher doses of DTG, (+)‐pentazocine and DHEA were required to elicit a selective potentiation of the NMDA response comparable to that obtained in control females.”