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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Dehydroepiandrosterone
drug:
Prednisolone
Research Papers that Mention the Interaction
“Results suggest that dehydroepiandrosterone is additive in its effect with prednisolone , whereas tamoxifen interacts synergistically, both providing steroid‐sparing effects.”
Interactions of Prednisolone and Other Immunosuppressants Used in Dual Treatment of Systemic Lupus Erythematosus in Lymphocyte Proliferation Assays“ Dehydroepiandrosterone (DHEA), both basal and stimulated, was significantly suppressed 24 h post prednisolone (P less than 0.001).”
“In contrast to cortisol, basal and peak DHEA remained suppressed 72 h post prednisolone (basal DHEA 9.1 +/- 1.1 nmol/L, P less than 0.05 vs. control; peak DHEA 20.0 +/- 3.3 nmol/L, P less than 0.01 vs. control).”
“ DHEA with an IC50 value of 13.4 microM was a thousand times less potent than PD which had an IC50 value of 5.4 nM. Synergy was observed between DHEA and PD.”
“The association of DHEA and PD could produce enhanced steroid effects in anti-inflammatory therapy.”
Synergistic interaction between dehydroepiandrosterone and prednisolone in the inhibition of rat lymphocyte proliferation.
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