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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Dehydroepiandrosterone
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“ DHEA in vitro significantly promotes NO synthesis, suppresses MDA and MCP-1 secretion of endothelial cells, and decreases ICAM-1, VCAM-1 and E-selectin expression in HUVECs; neither selective ERα antagonist (methyl-piperidino-pyrazole, MPP) nor ERβ antagonist (R,R-tetrahydrochrysene, R,RTHC) can abolish these effects.”
Protective effects of dehydroepiandrosterone on atherosclerosis in ovariectomized rabbits via alleviating inflammatory injury in endothelial cells.“In addition, recent studies in vitro have shown that DHEA has the capacity to improve endothelial function by increasing nitric oxide ( NO ) synthesis.”
“Albumin-conjugated DHEA also stimulated NO release, suggesting that DHEA stimulates eNOS by a plasma membrane-initiated signal.”
“These findings demonstrate that physiological concentrations of DHEA acutely increase NO release from intact vascular endothelial cells, by a plasma membrane-initiated mechanism.”
“We show that DHEA administration to human endothelial cells triggers nitric oxide synthesis, due to enhanced expression and stabilization of endothelial nitric oxide synthase (eNOS).”
“ DHEA 1) prevented platelet aggregation by 40% compared to control, 2) increased NO production by 63%, 3) increased p-eNOS (phosphorylated endothelial nitric oxide synthase) levels, and 4) increased cGMP production.”
“In light of these precedents and considering that DHEA is able to increase the production of NO in cultured endothelial cells, we suggest that DHEA prevents the aggregation of platelet from postmenopausal women with T2D through the activation of PKC/eNOS/NO/cGMP pathway.”
“Recently, it has been suggested that DHEAS can retard atherosclerosis formation through an increase in nitric oxide ( NO ) production by increasing E2 synthesis.”
“In addition, DHEA improved the phagocytic ability, enhanced the NO production and increased the iNOS activity in peritoneal macrophages.”
Effect of dehydroepiandrosterone on the immune function of mice in vivo and in vitro.“Zinc and DHEA supplementation exerted additive effects on the immune response by elevation of macrophage counts, and by increasing concentrations of IFN-gamma and NO.”
“ DHEA treatment promoted increased lymphoproliferative responses as well as enhanced concentrations of NO and IL-12.”
“ DHEA treatment augments NO production for both sexes after in vitro LPS treatment for uninfected animals.”
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