Possible Interaction: Dehydroepiandrosterone and Nerve Growth Factor

“For example, DHEA synthesized in the adrenal gland interferes directly with nerve growth factor (NGF) receptors, a major biochemical contributor to peripheral hypersensitivity.”

“Some SSRIs (e.g., fluvoxamine, fluoxetine and escitalopram) and other drugs (donepezil , ifenprodil , dehydroepiandeterone (DHEA)) potentiate nerve-growth factor (NGF)-induced neurite outgrowth in PC12 cells, and these effects could be antagonized by the selective sigma-1 receptor antagonist NE-100.”

“ DHEA lessened the positive effect of NGF on cell survival and neuronal differentiation.”

“ DHEA significantly elevated catecholamine release from unstimulated PC12 cells in the presence but not absence of NGF.”

“ Nerve growth factor (NGF)-mediated induction of a neuronal phenotype was inhibited by DHEA as indicated by reduced neurite outgrowth and decreased expression of neuronal marker proteins such as synaptosome-associated protein of 25 kDa and vesicle-associated membrane protein-2.”

“Cell survival promoted by NGF in serum‐deprived PC12 cells and neurite outgrowth was reduced by DHEA , pointing toward a role of DHEA in the differentiation process of chromaffin cells.”

“In this study, we investigated the possible role of DHEA to modulate NGF and BDNF production.”

“The results showed that NGF and BDNF are overproduced after DHEA treatment but there is not any overexpression for NT-3 and NT-4.”