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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Dehydroepiandrosterone
drug:
Metyrapone
Research Papers that Mention the Interaction
“Total testosterone (84 +/- 54 vs. -0.4 +/- 2 ng/dl, P = … vs. 0.1 +/- 0.1 pg/ml, P = 0.024), DHEA (5.0 +/- 3.2 vs. -0.6 +/- 0.5 microg/l, P = 0.… vs. -14 +/- 22 ng/dl, P = 0.024) levels increased in response to metyrapone ….”
Increased adrenal androgen secretion with inhibition of 11beta-hydroxylase in HIV-infected women.“Conversion of DHA to 7 alpha-OHDHA was inhibited by ketoconazole and metyrapone.”
“ Metyrapone and antipyrine also inhibited 7α‐hydroxylation, but by contrast, significantly increased 7β‐hydroxylation of DHEA.”
Dehydroepiandrosterone 7α‐ and 7β‐Hydroxylation in Mouse Brain Microsomes. Effects of Cytochrome P450 Inhibitors and Structure‐Specific Inhibition by Steroid Hormones
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