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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Dehydroepiandrosterone
drug:
Letrozole
Research Papers that Mention the Interaction
“Although letrozole decreased serum E2 levels in OVX mice treated with DHEA , it did not alter DHEA's effects on corresponding immunological changes due to OVX.”
DHEA prevents bone loss by suppressing the expansion of CD4(+) T cells and TNFa production in the OVX-mouse model for postmenopausal osteoporosis.“The blockade of the synaptic response to DHEA by letrozole , despite the lack of a uterotrophic response to this steroid, suggests that the hippocampal response to DHEA may be mediated via aromatization in the brain.”
“The effect of DHEA on CA1 synapse density was abolished by pretreatment with the nonsteroidal aromatase inhibitor, letrozole.”
Dehydroepiandrosterone increases hippocampal spine synapse density in ovariectomized female rats.
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