Possible Interaction: Dehydroepiandrosterone and Leptin

“2] Acute increase in insulin levels during OGTT is associated with an increase in levels of sOB-R. [3] DHEAS may play a role in leptin bioavailability by modulating sOB-R levels.”

“Several studies have demonstrated that DHEA may also regulate the expression and secretion of adipokines such as leptin , adiponectin, and resistin.”

“On the contrary, dihydrotestosterone, androstenedione and dehydroepiandrosterone-S are potent inhibitors of leptin secretion, while estradiol induces a strong stimulation in adipose tissue taken from women.”

“Patients receiving DHEA substitution displayed lower leptin and adiponectin levels (p < 0.05).”

“Moreover, in adipose tissue of women, the estrogen precursors testosterone (100 nM) and dehydroepiandrosterone (1 µM) also induced an increase in leptin secretion (+84 and +96%, respectively), an effect that was prevented by the aromatase inhibitor letrozole.”

“ DHEA treatment increased serum leptin content in HMG and HHG groups compared with that in HCG group.”

“Our results further suggest a protective effect of DHEA on adipose tissue by upregulating PPARalpha and downregulating leptin , thereby contributing to the reduced expression of 11beta-HSD1.”

“Thus, DHEA may exert a small, independent effect on leptin levels in this animal model, but the reduction is less than what would be expected.”