Possible Interaction: Dehydroepiandrosterone and Interleukin-10

“RESULTS DH A de creased the release of IL-2 and IL- 10 in directly (anti-CD3) and indirectly (PHA)-stimulated T cells from postoperative samples, whereas the release of interferon gamma in PHA-stimulated T cells was not affected.”

“Results In PBMCs from subjects exhibiting methacholine airway hyperresponsiveness (AHR), DHEA significantly suppressed IL-10 , IL-5, and IFN-γ production in a dose-dependent manner (all p<0.001) and tended to increase the IFN-γ/IL-5 ratio (p=0.087).”

“Furthermore, DHEA significantly increased the Th1 type cytokine (IL-2 and IFN-α) and decreased the Th2 type cytokine (IL-4 and IL-10 ) levels in LPS-induced mice or in primary cultured spleen T lymphocytes.”

“ DHEA alone and combined with infection and stress significantly increased IL-10 and IL-4 levels.”

“Increasing concentrations of DHEA significantly increased the production of the Th2 cytokine IL-10 but had no effect on the production of the Th2 cytokine IL-4, the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha), or IL-6.”

“Moreover, DHEA reduced splenocyte and splenic M phi anti-inflammatory cytokine (i.e., IL-10 ) production after TH compared with vehicle-treated females.”

“Results indicate that treatment with DHEA or DHEAS significantly increases the serum level of IL-10.”

“Thus, DHEA might affect the function of B lymphocytes via stimulating IL-10 production.”

“The effect of DHEA paralleled a delay in the expression of IL-10 and IL-6 and an earlier detection of IL-12 transcripts.”

“Serum levels of IL-10 , which increase with onset of disease, were also significantly reduced in mice treated with DHEAS beginning at 2 months of age.”