Possible Interaction: Dehydroepiandrosterone and Insulin

“Fasting plasma insulin and glucagon were lower with DHEA (42 +/- 4.94 vs. 53 +/- 6.58 pmol/l [P = 0.005] and 178 +/- 11.32 vs. 195.04 +/- 15 pmol/l [P = 0.02], respectively).”

“In conclusion, replacement therapy with 50 mg of DHEA for 12 weeks significantly increased insulin sensitivity in hypoadrenal women, thereby suggesting that DHEA replacement could have a potential impact in preventing type 2 diabetes.”

“High insulin concentrations may further lower DHEA and DHEA-S levels.”

“OBJECTIVE Insulin was found to decrease the concentration of serum dehydroepiandrosterone (DHEA) and DHEA‐sulphate (DHEAS) and recent data suggest that an increase in the metabolic clearance rate of DHEA (MCRDHEA) may be involved.”

“In rodents, DHEA decreases the severity of genetic and …-supplemented patient has been described.3 Additionally, 17-hour DHEA … insulin a ~ t i o n , ~ and 3 weeks of oral DHEA increases T-lymphocyte insulin … preparation of DHEA that recreates the reproductive age adrenal androgen milieu in elderly subjects.?”

“ Dehydroepiandrosterone enhanced tissue insulin sensitivity and lowered serum triglycerides.”

“MCR of dehydroepiandrosterone rose in men during the insulin infusion from 2443 +/- 409 to 3599 +/- 500 liters/24 h (P = 0.003), but did not change during the control saline infusion.”

“These findings suggest that insulin acutely increases the MCR of dehydroepiandrosterone in men but not in women.”

“To test the hypothesis that insulin acutely enhances the metabolic clearance rate (MCR) of dehydroepiandrosterone in humans, the effect of a short-term insulin infusion on the MCR of dehydroepiandrosterone was assessed in 10 men and 7 women.”

“ DHEA and DHEA-sulfate (DHEA-S) have been reported to increase not only insulin secretion of the pancreas but also insulin sensitivity of the liver, adipose tissue, and muscle.”

“ DHEA alone affected neither plasma glucose nor lipid levels, while it increased insulin sensitivity and diminished both renal and hepatic G6Pase activities.”

“ DHEA has been shown to modulate insulin signaling pathways, enhance glucose uptake in adipocytes, and increase insulin sensitivity in patients with DHEA deficiency or abnormal glucose tolerance.”

“ DHEA increases not only insulin sensitivity due to the effects in the liver and muscle, but also insulin secretion.”