Effects of dehydroepiandrosterone and alprazolam on hypothalamic-pituitary responses to exercise.

 would enhance and APZ would blunt exercise-induced ACTH and 

Levels of DHEA and DHEAS and responses to CRH stimulation and hydrocortisone treatment in chronic fatigue syndrome

 (8.9+/-0.97 ng/ml, P=0.015) and DHEAS (233.4+/-41.6 microg/dl, P=0.03) were lower in patients following treatment with 

Influence of DHEA Administration on 24-Hour Cortisol Concentrations

 concentrations merits further investigation.

Altered salivary dehydroepiandrosterone levels in major depression in adults

 and may have mood improving properties, these findings may have significant implications for the pathophysiology of depression.

A comparison of two types of anaesthesia on the endocrine and metabolic responses to anaesthesia and surgery.

 secretion closely followed the secretory profile of 

Hydrocortisone alone vs hydrocortisone plus aminoglutethimide: a comparison of the endocrine effects in postmenopausal breast cancer.

Effects of DHEA on metabolic and endocrine functions of adipose tissue

Additionally, by suppressing the activity of 11β-hydroxysteroid dehydrogenase 1 in adipocytes,

 may promote intra-adipose inactivation of 

Control of adrenal androgen secretion.

Rosenfield et al. (1) studied endogenous cortisol and dehydroepiandrosterone (DHA) secretion in a normal volunteer and found a correlation between the rhythmicity of secretion of

, although the magnitude of the DHA rhythm was much less than that of cortisol.

Impact of short-term hydrocortisone intake on pituitary and adrenal function in healthy young male subjects

Once-daily oral therapeutic administration of

 secretion by inhibiting pituitary ACTH, but this effect seemed transient without significant impairment of basal adrenal or pituitary function 24 h after administration.

Sex-specific associations between person and environment-related childhood adverse events and levels of cortisol and DHEA in adolescence

 may have a protective function against long-term exposure to increased levels of 

, but has been little investigated in relation to childhood adversity.

Role of DHEA and cortisol in prefrontal-amygdalar development and working memory

Taken together, these findings support the notion, as suggested by animal and in vitro studies, that there are opposing effects of

 on brain development in humans, and that these effects may especially target prefrontal-amygdalar development and working memory, in a lateralized fashion.

There is accumulating evidence that both dehydroepiandrosterone 

 play an important role in regulating physical maturation and brain development.

Stress Physiology and Memory for Emotional Information: Moderation by Individual Differences in Pubertal Hormones

 further interacted with pubertal hormones (testosterone and 

Cortisol and DHEA in development and psychopathology

Along the way, we identify several major knowledge gaps in the role of

 in typical development and developmental psychopathology with implications for future research.

 has stimulated interest in examining their levels as a ratio, as an alternate index of adrenocortical activity and the net effects of cortisol.

Physiologic data support the notion of opposing effects of

Role of spliceosome proteins in the regulation of glucocorticoid receptor isoforms by cortisol and dehydroepiandrosterone

 by modulating the glucocorticoid receptor &bgr; (GR&bgr;) expression and antagonizing the binding of GR&agr; to the glucocorticoid responsive element (GRE) in RACK1 (Receptor for Activated C Kinase 1) promoter.

The impact of peri-operative dexamethasone administration on the normal hypothalamic pituitary adrenal response to major surgical procedures

 rise was paralleled by an equimolar increase in 

 and a subsequent increase in DHEA-S levels.

The “yin and yang” of the adrenal and gonadal systems in elite military men

 and testosterone modestly and less robustly predicted 

 concentrations; this was confined to the morning, and testosterone was the primary predictor.

Dehydroepiandrosterone improves the ovarian reserve of women with diminished ovarian reserve and is a potential regulator of the immune response in the ovaries.

 has a pro-inflammatory immune function that opposes 

DHEA modulates the effect of cortisol on RACK1 expression via interference with the splicing of the glucocorticoid receptor

 on RACK1 expression, a protein required both for the correct functioning of immune cells and for PKC‐dependent pathway activation, but also modulates the inhibitory effect of cortisol on LPS‐induced cytokine production.

Diurnal patterns and associations among salivary cortisol, DHEA and alpha-amylase in older adults

 was found to change during the course of the day.

The Relationship between Dehydroepiandrosterone (DHEA), Working Memory and Distraction – A Behavioral and Electrophysiological Approach

Overall, the results suggest that in women

 effects reducing distraction and that a higher DHEA response may enhance working memory at the electrophysiological level.

Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake

, negating the requirement for 11β-HSD1 oxoreductase activity, diminished the inhibitory effect of 

Perceived stress at work is associated with attenuated DHEA-S response during acute psychosocial stress

) and dehydroepiandrosterone sulfate (DHEA-S) have been suggested to play a protective role during acute psychosocial stress, because they act as antagonists to the effects of the stress hormone 

Differences between diurnal patterns of salivary cortisol and dehydroepiandrosterone in healthy female adolescents

Similarly, the association between evening

 was characterised as a trend (p = 0.084).

Cortisol stimulates secretion of dehydroepiandrosterone in human adrenocortical cells through inhibition of 3betaHSD2.

 was associated with competitive inhibition of 3βHSD2 activity.

Functional mapping of the promoter region of the GNB2L1 human gene coding for RACK1 scaffold protein.

In conclusion we hypothesize that the imbalance between

 during aging could be important in the previously demonstrated recovery of the RACK1 expression.

The endocrine profiles in men with localized and locally advanced prostate cancer treated with radical prostatectomy.

Significant correlation was found between serum levels of

 in both groups (p<0.02), estradiol and prolactin in patients with locally advanced prostate cancer, as well between LH and prolactin (p<0.05).

DHEA SUPPLEMENTATION AND COGNITION IN POSTMENOPAUSAL WOMEN

Ginseng enhances the effectiveness of DHEA

I appreciated the RCT on the efficacy of ginseng for preventing upper respiratory tract infections.[1][1] I suggest

 (DHEA) activity and is the basis of the “fight or flight mechanism.”

The influence of 10 min of the Johrei healing method on laboratory stress.

IgA levels were unchanged but cortisol levels were found to be slightly but non-significantly lower after Johrei than after the control condition and DHEA levels slightly but non-significantly raised, with a negative correlation between

Adrenal and gonadal hormone variations during a febrile attack in a woman with tumor necrosis factor receptor-associated periodic syndrome.

Role of dehydroepiandrosterone sulfate levels on body composition after laparoscopic adjustable gastric banding in pre-menopausal morbidly obese women

 (DHEAS) has been postulated to have anabolic and lipolytic properties that could potentially counteract the catabolic effect of 

Neuroendocrine hypothesis of aging: the role of corticoadrenal steroids.

) circadian fluctuation and the progressive decrease of DHEA/cortisol ratio are at the basis of multiple clinical implications: the shift from anabolic to …, the activation of atherosclerosis progression, the deterioration of immune competence, the impairment of cognitive and affective performances and the glico- and lipometabolic disorders.

[Study of the stress response: role of anxiety, cortisol and DHEAs].

, as shown by the close correlation between both hormones (r=0,433, p=0,0033, Spearman test).

The hypothesis of an antagonism between these two hormones is based on the fact that

This beneficial role could be related to a double action of

: a direct effect provided by its transformation into sexual hormones, an indirect one mediated by its competition with 

, of which the synthesis and consequently the activity decrease.

Cortisol/DHEA Ratios in Depression

 in the brain suggests that measurement of cortisol alone may provide an incomplete estimate of hypercortisolemia (Goodyer et al. 1998).

Elevation of the cortisol-dehydroepiandrosterone ratio in drug-free depressed patients.

 (DHEA) has antiglucocorticoid properties that may offer protection against the deleterious effects of 

Age-related changes of the adrenal secretory pattern: possible role in pathological brain aging

 play opposite effects on the central nervous system, the evaluation of the ratio between cortisol and DHEAS seems to be a good marker of the neuroendocrine features in old subjects.

 showed a significant age-related increase; the occurrence of senile dementia and of major depression played an additive role, by comparison to physiological aging.

Possible role of cortisol and dehydroepiandrosterone in human development and psychopathology

 and gonadal steroids may modulate the actions of 

Immunoendocrinologic Abnormalities in Human Immunodeficiency Virus Infection

Cortisol levels increase in HIV infection, while those of

 (DHEA), a physiologic antagonist of the immunoregulatory activities of 

Opposing effects of dehydroepiandrosterone and dexamethasone on the generation of monocyte-derived dendritic cells.

 often oppose those of the other adrenal glucocorticoid, 

Severity of depression in abstinent alcoholics is associated with monoamine metabolites and dehydroepiandrosterone-sulfate concentrations

 and its sulfate (DHEA and DHEA-S) may antagonize 

 and may have mood-elevating effects on their own.

A possible role for the cortisol/anticortisols imbalance in the progression of human immunodeficiency virus

Cortisol levels are increased in HIV infection whereas those of

The effect of ACTH therapy on serum dehydroepiandrosterone, androstenedione, testosterone and 5 alpha-dihydrotestosterone in infants.

 concentrations increased 2.3-fold, androstenedione 12.3-fold, testosterone 2.7-fold, 5 alpha-dihydrotesterone 2.5-fold and 

 2.9-fold compared to pre-therapy values.

Endocrine modulation of Brucella abortus-infected osteocytes function and osteoclastogenesis via modulation of RANKL/OPG.

This expression was increased when cortisol was incorporated during the infection and

 treatment partially reversed the effect of 

The expression of serum steroid sex hormones and steroidogenic enzymes following intraperitoneal administration of dehydroepiandrosterone (DHEA) in male rats

 administration, with serum DHEA-S, T, E(2) and Cor levels peaking at 1.5 h. Over time, steroid hormone levels were depressed, but … expression at 12 and 24 h, and CYP17alpha and 17beta-HSDIII expression at 12 h in the 100 mg kg(-1) DHEA group.

Dehydroepiandrosterone decreases while cortisol increases in vitro growth and viability of Entamoeba histolytica.

 increased the parasite's DNA synthesis determined by 3H-thymidine incorporation.

On the origin of dehydroepiandrosterone sulphate in the blood of fetal sheep.

 at term (1 mg/h for 84 h) raised levels of total oestrone in intact (n = …; 14.2 +/- 2.6 vs 190.6 +/- 53.0 nmol/l) fetuses and of total 

 in hypophysectomized fetuses (n = 7; 16.0 +/- 1.…/h) was without significant effect in any group.

DHEA Moderates the Impact of Childhood Trauma on the HPA Axis in Adolescence

Furthermore, high DHEA/cortisol ratios are often conceptualized as better markers of DHEA's availability than DHEA alone, as ratios account for the coupling of

Furthermore, high DHEA/cortisol ratios are often conceptualized as better markers of DHEA’s availability than DHEA alone, as ratios account for the coupling of

Effect of Mindfulness-Based Stress Reduction (MBSR) on dehydroepiandrosterone-sulfate (DHEAS) in adults with self-reported stress. A randomized trial.

 (DHEA) and its sulfated form dehydroepiandrosterone-sulfate (DHEAS), together DHEA(S), have shown to counteract some of the effects of 

Do Dehydroepiandrosterone (DHEA) and Its Sulfate (DHEAS) Play a Role in the Stress Response in Domestic Animals?

 to improve the definition of the stress phenotype in farmed animals is discussed.

The Value of Adrenal Androgens for Correcting Cortisol Lateralization in Adrenal Venous Sampling in Patients with Normal Cortisol Secretion

Significant positive correlations were observed between the

 concentrations and both androstenedione and 

 concentrations in the right and left adrenal veins.

Role of androgens in dhea-induced rack1 expression and cytokine modulation in monocytes

BackgroundOver the past fifteen years, we have demonstrated that

 (DHEA) have opposite effects on the regulation of protein kinase C (PKC) activity in the context of the immune system.

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Possible Interaction: Dehydroepiandrosterone and Hydrocortisone

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Research Papers that Mention the Interaction