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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Dehydroepiandrosterone
drug:
Haloperidol
Research Papers that Mention the Interaction
“This potentiating effect of DHEA was suppressed by the selective sigma 1 antagonist NE-100 and by the non-selective sigma antagonist haloperidol.”
Potentiation by dehydroepiandrosterone of the neuronal response to N-methyl-D-aspartate in the CA3 region of the rat dorsal hippocampus: an effect mediated via sigma receptors.“The effect of DHEA was reversed by the selective sigma antagonist N-dipropyl-2-(4-methoxy-3- (2-phenylethoxy)phenyl)- ethylamine monohydrochloride (NE-100) and by haloperidol , but not by spiperone.”
“The sigma antagonists haloperidol and 1-[2-(3,4-dichlorophenyl)-ethyl]-4-methylpiperazine, although inactive by themselves, completely prevented the effects of DHEA S , PREG S, and 1,3-di(2-tolyl)guanidine on NMDA-evoked [3H]NE release.”
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