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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Dehydroepiandrosterone
supplement:
Glutathione
Research Papers that Mention the Interaction
“Inhibition of the platelet glutathione redox cycle with 1,3-bis(2-chloroethyl)-1-nitrosourea, dehydroepiandrosterone , or 1-chloro-2,4-dinitrobenzene interfered with platelet protective effects.”
Washed human platelets prevent ischemia-reperfusion edema in isolated rabbit lungs.“ DHEA inhibits G6PDH from healthy erythrocyte and decreases GSH content in both erythrocytes and P. falciparum.”
“Dehydroepiandrosterone DHEA ) inhibits glucose 6-phosphate dehydrogenase (G6PDH) of different species and may potentially decrease intracellular glutathione.”
“The G6PD inhibitors DHEA dehydroepiandrosterone ) and 6-AN (6-aminonicotinamide) reversed the increase of G6PD and GSH and inhibited MDR both in HT29-DX cells and in HT29 cells overexpressing G6PD.”
“ DHEA up-regulated the expression of γ-glutamylcysteine synthetase, a rate-limiting enzyme of glutathione (GSH) synthesis, and the levels of GSH to maintain PP2A activity.”
“Inhibition of the pentose phosphate pathway by trans-dehydroepiandrosterone (DHEA ) suppressed ribose 5-phosphate levels and production of reduced glutathione , as well as insulin secretion in INS-1 832/13 β-cells and rat islets without affecting ATP production.”
Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.“ DHEA treatment significantly increased total glutathione content (17%) and GSH (22%) in 3- and 24-month-old treated groups when compared to control groups.”
“Moreover, DHEA diminished the content of the anti‐oxidant molecule glutathione ( GSH ), whereas M and DHEA + metformin increased GSH levels and diminished lipid peroxidation.”
“The antioxidant metabolite glutathione diminished during both DHEA treatments.”
“In agreement with previous studies showing a prooxidant effect of DHEA, here we show that pharmacological doses of DHEA produce increased H(2)O(2) levels and a marked reduction of GSH content in rat liver.”
“ASM and DHEA treatments suppressed the contents of AsA, GSH and NADPH, and expression of MdSOD, MdAPX and MdMDHAR.”
The role of glucose-6-phosphate dehydrogenase in reactive oxygen species metabolism in apple exocarp induced by acibenzolar-S-methyl.
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