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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Dehydroepiandrosterone and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

We found both N-methyl-d-aspartate and sigma 1 antagonists, but not GABA antagonists, could completely eliminate the effects of DHEA on stem cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America  •  2004  |  View Paper
DHEA has been postulated to function as an excitory neuroregulator, antagonizing g-aminobutyric acid transmission.
L'Encephale  •  2002  |  View Paper
In vitro studies have demonstrated that DHEA-S, and perhaps DHEA , have GABA antagonistic activity.
Journal of clinical psychopharmacology  •  1999  |  View Paper
DHEA (100 μM) and DHEA-S (100 μM) also attenuated the effect of GABA.
Journal of psychopharmacology  •  2010  |  View Paper
Pulse-chase experiments showed that GABA inhibited in a dose-dependent manner the conversion of tritiated pregnenolone into radioactive steroids, including 17-hydroxy-pregnenolone, progesterone, 17-hydroxy-progesterone, dehydroepiandrosterone , and dihydrotestosterone.
Proceedings of the National Academy of Sciences of the United States of America  •  2000  |  View Paper
In contrast, DHEAS, but not DHEA , inhibited the binding of [3H]GABA and [35S]TBPS to rat brain cerebral cortical and cerebellar membranes in a concentration-dependent manner.
The Journal of pharmacology and experimental therapeutics  •  1997  |  View Paper
These findings indicate that exogenous application and endogenous stimulation of DHEAS modulates hippocampal GABA inhibition in a physiologically relevant manner possibly by entraining hippocampal neurons to theta rhythm.
Hippocampus  •  1995  |  View Paper