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Possible Interaction: Dehydroepiandrosterone and Flutamide

Research Papers that Mention the Interaction

Flutamide , ketoconazole, and EE-CPA induced a significant decrease in total and free testosterone, 5alpha-dihydrotestosterone, dehydroepiandrosterone , dehydroepiandrosterone sulfate, and androstenedione plasma levels.
The Journal of clinical endocrinology and metabolism  •  1999  |  View Paper
In vitro, 3 micromol/L flutamide suppressed DHEA , androstenedione and androstenediol synthesis compared with bicalutamide in a medium of adrenal cancer cell line.
The lower DHEA group improved the duration of responsiveness to flutamide.
International journal of urology : official journal of the Japanese Urological Association  •  2010  |  View Paper
The pure antiandrogens Flutamide and Hydroxyflutamide reversed the inhibitory effect of DHEA on MCF-7 cell growth, whereas both the nonsteroidal estrogen Diethylstilbestrol and the antiestrogen Tamoxifen were ineffective.
Anticancer research  •  1993  |  View Paper
Furthermore, flutamide ameliorated the inhibitory effect on cell proliferation and promotive effect on cell apoptosis by DHEA.
Journal of cellular physiology  •  2019  |  View Paper
In both THP-1 cells and human peripheral blood mononuclear cells (PBMC), flutamide blocked the effects of DHEA , suggesting a role of the AR in these effects.
ResultsHere we demonstrated the ability of the anti-androgen molecule, flutamide , to counteract the stimulatory effects of DHEA on RACK1 and GRβ expression, and cytokine production.
Immunity & Ageing  •  2016  |  View Paper
The hormone-receptor antagonists ICI 182780 and flutamide failed to abrogate the antiviral effect of DHEA.
The Journal of general virology  •  2005  |  View Paper
As in males, flutamide in females increased CA1 spine synapse formation and further augmented the response to DHEA.
By contrast, flutamide alone (2 d; 5 mg/d, sc) increased CA1 spine synapse density by 66%, whereas in combination the effects of flutamide and DHEA were additive rather than inhibitory.
Endocrinology  •  2004  |  View Paper
The addition of Flutamide to DHEA treatment completely prevented the DHEA-induced changes in the sebaceous glands, whereas the antiestrogen EM-800 had no effect.
The Journal of endocrinology  •  2000  |  View Paper
The above stimulatory effect of DHEA on trabecular number was reversed by 54% (P < 0.01) by the administration of FLU , which also reversed by 29% the decrease in intertrabecular area caused by DHEA administration.
The administration of FLU reversed by 76% the stimulatory effect of DHEA on femoral BMD and completely prevented the stimulatory effect of DHEA on total body and lumbar spine BMD.
While DHEA treatment partially reversed the marked inhibitory effect of OVX on the tibial trabecular bone volume, the administration of FLU inhibited by 51% (P < 0.01) the stimulatory effect of DHEA on this parameter.
The Journal of endocrinology  •  1998  |  View Paper