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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Dehydroepiandrosterone
drug:
Flutamide
Research Papers that Mention the Interaction
“ Flutamide , ketoconazole, and EE-CPA induced a significant decrease in total and free testosterone, 5alpha-dihydrotestosterone, dehydroepiandrosterone , dehydroepiandrosterone sulfate, and androstenedione plasma levels.”
A prospective randomized trial comparing low dose flutamide, finasteride, ketoconazole, and cyproterone acetate-estrogen regimens in the treatment of hirsutism.“Furthermore, flutamide ameliorated the inhibitory effect on cell proliferation and promotive effect on cell apoptosis by DHEA.”
“The pure antiandrogens Flutamide and Hydroxyflutamide reversed the inhibitory effect of DHEA on MCF-7 cell growth, whereas both the nonsteroidal estrogen Diethylstilbestrol and the antiestrogen Tamoxifen were ineffective.”
“The hormone-receptor antagonists ICI 182780 and flutamide failed to abrogate the antiviral effect of DHEA.”
Antiviral effect of dehydroepiandrosterone on Japanese encephalitis virus infection.“As in males, flutamide in females increased CA1 spine synapse formation and further augmented the response to DHEA.”
“By contrast, flutamide alone (2 d; 5 mg/d, sc) increased CA1 spine synapse density by 66%, whereas in combination the effects of flutamide and DHEA were additive rather than inhibitory.”
“The addition of Flutamide to DHEA treatment completely prevented the DHEA-induced changes in the sebaceous glands, whereas the antiestrogen EM-800 had no effect.”
“The above stimulatory effect of DHEA on trabecular number was reversed by 54% (P < 0.01) by the administration of FLU , which also reversed by 29% the decrease in intertrabecular area caused by DHEA administration.”
“The administration of FLU reversed by 76% the stimulatory effect of DHEA on femoral BMD and completely prevented the stimulatory effect of DHEA on total body and lumbar spine BMD.”
“While DHEA treatment partially reversed the marked inhibitory effect of OVX on the tibial trabecular bone volume, the administration of FLU inhibited by 51% (P < 0.01) the stimulatory effect of DHEA on this parameter.”
“In both THP-1 cells and human peripheral blood mononuclear cells (PBMC), flutamide blocked the effects of DHEA , suggesting a role of the AR in these effects.”
“ResultsHere we demonstrated the ability of the anti-androgen molecule, flutamide , to counteract the stimulatory effects of DHEA on RACK1 and GRβ expression, and cytokine production.”
Role of androgens in dhea-induced rack1 expression and cytokine modulation in monocytes
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