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Last Updated: 2 years ago

Possible Interaction: Dehydroepiandrosterone and Estrone

Research Papers that Mention the Interaction

CONCLUSION(S) Administration of low doses (25 mg) of DH A po sitively modulates several endocrine parameters in early and late postmenopausal women, inducing the increase of the androgenic, est rogenic, a nd progestogenic milieu and reducing the climateric symptoms, similarly to estroprogestin replacement therapy.
Fertility and sterility  •  2003  |  View Paper
Clinical studies carried out in small groups of subjects have clearly demonstrated that the administration of DHEA to the elderly increases many hormone levels, including that of insulin-like growth factor-1, (free and total) testosterone, dihydrotestosterone, oestrone and oestradiol.
Bailliere's clinical endocrinology and metabolism  •  1998  |  View Paper
However, DHEA regimen is also associated with an increased estrogenic availability.
Journal of Endocrinological Investigation  •  2020  |  View Paper
Moreover, DHEA administration enhanced serum levels of DHEA, DHEAS, testosterone, and estrone , and regression analyses demonstrated that levels of DHEA and its metabolites were positively related to cognitive performance on the visual-spatial tasks in the DHEA condition.
Behavioral neuroscience  •  2011  |  View Paper
RESULTS DH A tr eatment with exercise resulted in increases in circulating sulfated DHEA (650%), total testosterone (100%), estradiol (165%), est rone (8 5%), and IGF-I (30%) (all P < or = 0.05, for all within and between treatment comparisons).
The Journal of clinical endocrinology and metabolism  •  2008  |  View Paper
The K(m) of estrone is more than 1000-fold lower than that of DHEA and the K(m) of estradiol is about 10 times lower than that of DHT.
The Journal of biological chemistry  •  2000  |  View Paper
A significant correlation between formation of estrone and dehydroepiandrosterone occurred for all cell lines (r = 0.98, P less than 0.001) indicating that the same 17 beta-hydroxysteroid dehydrogenase was probably involved.
Journal of steroid biochemistry  •  1989  |  View Paper
Dehydroepiandrosterone had only 1% the inhibitory activity of estrone.
The Journal of clinical endocrinology and metabolism  •  1984  |  View Paper
Equimolar concentrations of dehydroepiandrosterone, estrone or estradiol cause significant inhibition (to 50%) of this activity but dehydroepiandrosterone sulfate and estriol did not.
The Journal of clinical endocrinology and metabolism  •  1982  |  View Paper
For example, estrone and estradiol-17 beta inhibit the oxidation of both substrates competitively with Ki values of between 15 and 24nM. The Km values of dehydroepiandrosterone and pregnenolone with NADP+ as cofactor are higher than those with NAD+ as cofactor and the V values are much lower.
Steroids  •  1981  |  View Paper
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