Possible Interaction: Dehydroepiandrosterone and Estradiol

“Daily administration of 25 mg DHEA increased the serum DHEA, DHEAS, androstenedione, and estradiol levels of the subjects of the older group to the same level as that of younger subjects.”

“Finally, DHEA administration induced a significant and dose dependent increase of plasma estrogens and particularly of estradiol.”

“ DHEA metabolites, but not DHEA, competed with 17β-estradiol for ERα and ERβ binding and stimulated MCF-7 cell proliferation, demonstrating that DHEA metabolites interact directly with ERα and ERβin vitro, modulating estrogen target genes in vivo.”

“Clinical studies carried out in small groups of subjects have clearly demonstrated that the administration of DHEA to the elderly increases many hormone levels, including that of insulin-like growth factor-1, (free and total) testosterone, dihydrotestosterone, oestrone and oestradiol.”

“Serum testosterone and DHEA sulfate levels along with higher estradiol levels were significantly higher in the DHEA group.”

“ Oestradiol levels were equally suppressed during pill intake, whether with placebo or DHEA.”

“Treatment with DHEA resulted in a significant increase of total testosterone, estradiol and DHEA-S levels in treated subjects versus the placebo group (P < 0.05).”

“A favourable decrease was noted in mean day 3 serum oestradiol concentrations after DHEA supplementation (75.14 +/- 28.93 versus 43.07 +/- 11.77; P < 0.01).”

“RESULTS DH A tr eatment with exercise resulted in increases in circulating sulfated DHEA (650%), total testosterone (100%), est radiol (1 65%), estrone (85%), and IGF-I (30%) (all P < or = 0.05, for all within and between treatment comparisons).”

“In mixed RA synoviocytes, DHEA conversion yielded high local levels of 17beta-estradiol (708 pmol/l = 0.193 ng/ml) compared to testosterone (88 pmol/l = 0.026 ng/ml).”