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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Dehydroepiandrosterone
drug:
Dinoprostone
Research Papers that Mention the Interaction
“Secretion of PGE2 induced by PDGF was augmented by pretreatment with DHEA.”
“These results suggest that DHEA inhibited MAPK activation induced by PDGF-BB via PGE2 overproduction and subsequent cAMP-dependent pathway in human male aortic SMCs.”
Effects of dehydroepiandrosterone on mitogen-activated protein kinase in human aortic smooth muscle cells.“ DHEA suppressed the expression of MMP-1, -3 and -13 genes and PGE2 protein synthesis enhanced by lipopolysaccharide (LPS) while the COX-II and inducible nitric oxide synthase (iNOS) gene expressions were down-regulated by DHEA.”
The in vitro effects of dehydroepiandrosterone on chondrocyte metabolism.“In cultured rat mesangial cells, DHEF (and DHEA ) potently inhibited interleukin-1beta-induced cyclooxygenase-2 (COX2) mRNA and prostaglandin ( PGE2 ) production.”
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