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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Dehydroepiandrosterone
drug:
Dextromethorphan
Research Papers that Mention the Interaction
“Thymocyte apoptosis induced by DEX treatment was significantly lowered in DHEA‐ and 7α‐hydroxy‐DHEA‐treated thymi, even after 18 h culture with additional 10−6 mol/L DEX.”
Dexamethasone‐induced apoptosis of mouse thymocytes: Prevention by native 7α‐hydroxysteroids“However, DHEA added to lymphocyte cultures in vitro over a concentration range from 10(-7)-10(-8) M failed to protect against suppression of mitogenic responses caused by addition of DEX to cultures.”
“In summary, DHEA given in vivo antagonizes the suppressive actions of DEX on lymphoid target tissues in mice.”
“Pretreatment of mice with sc DHEA (60 mg/kg.day) for 3 days in vivo antagonized the profound suppression of in vitro blastogenic responses seen in T- and B-lymphocytes after a single injection of dexamethasone ( DEX ; 60 mg/kg).”
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