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“In permeabilized cells, DHEA suppressed the Ca <sup>2+</sup>-induced secretion.”
“Using bovine chromaffin cells, we found that DHEA inhibited catecholamine secretion and cytosolic Ca <sup>2+</sup> ([Ca<sup>2+</sup>]<sub>i</sub>) rise coupled with nicotinic acetylcholine receptor (nAChR) without exerting an effect on <sup>3</sup>H-nicotine binding.”
“Acute treatment with DHEA , but not with DHEA-S, significantly inhibited nitric oxide (NO) production and Ca2+ -sensitive NO synthase (NOS) activity caused by NMDA stimulation.”