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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Dehydroepiandrosterone and Becaplermin

Research Papers that Mention the Interaction

Only MAPK activation induced by PDGF-BB was reduced by pretreatment with DHEA , although DHEA did not affect the MAPK activation induced by EGF or bFGF.
The increase of cAMP by PDGF-BB was augmented by pretreatment with DHEA , although DHEA alone did not affect cAMP.
These results suggest that DHEA inhibited MAPK activation induced by PDGF-BB via PGE2 overproduction and subsequent cAMP-dependent pathway in human male aortic SMCs.
Life sciences  •  1999  |  View Paper