Possible Interaction: Dehydroepiandrosterone and Adrenocorticotropic Hormone

“The DHEA deltaAUCs to all ACTH doses were significantly higher (P < 0.01) than that after placebo, showing a clear dose-response relationship (P < 0.001).”

“In man, … and DHEA concentrations were rapidly stimulated two-fold in the first 30 min following the administration of ACTH , while PREG-FA and DHEA-FA levels were increased by approximately 2.5-fold (P less than 0.01) at 120 and 180 min.(ABSTRACT TRUNCATED AT 250 WORDS)”

“ ACTH stimulates production of dehydroepiandrosterone (DHA), the major steroid product of the fetal zone, and of cortisol, the characteristic steroid product of the definitive zone.”

“Dynamic tests were also carried out: ACTH stimulation was found to increase delta 4, DHA and 11 beta OH delta 4.”

“ ACTH also significantly increased transcript levels for all of the steroidogenic enzymes required to produce aldosterone, cortisol, and dehydroepiandrosterone , as well as MC2R mRNA.”

“Treatment with ACTH significantly increased aldosterone, cortisol, and dehydroepiandrosterone production in H295RA cells.”

“ ACTH increased the mean AV concentration of DHEA-S by 5-fold, DHEA by 21-fold, A4 by 7-fold, and 11OHA by 5-fold.”

“The present results show decreased secretion of cortisol and DHEA in RA patients in response to ACTH , suggesting a subtle HPA hypofunction at the adrenocortical level.”

“In ANW both ACTH doses induced significant (p<0.05) F and DHEA increases which were not significantly different from those in HW, though a trend toward a lower cortisol response after ACTH 0.06 μg/m2 in ANW was present.”

“Like in HW, in ANW the maximal ACTH dose induced F and DHEA increases greater (p<0.01) than those induced by the lowest dose.”

“While ACTH is a potent stimulator of DHEA secretion, other factors both systemic and local have been involved in adrenal androgen control.”

“We demonstrated that 1 microg ACTH significantly elevates DHEA levels, with no difference in output between CFS and healthy subjects.”