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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Dehydroascorbic Acid
supplement:
Vitamin C
Research Papers that Mention the Interaction
“Hence, a progressive increase in extracellular DHA concentrations in the presence of a fixed amount of AA caused an initial decrease in the net amount of vitamin C accumulated, and eventually, at higher levels, it caused an accumulation of the vitamin solely based on DHA uptake through hexose transporters.”
“Results obtained with different experimental approaches showed that DHA potently and reversibly inhibits AA uptake through Na(+)-AA cotransporters.”
A novel biological role of dehydroascorbic acid: Inhibition of Na(+)-dependent transport of ascorbic acid.“On the other hand, elevation of intracellular concentration of ascorbic acid by treatment with ascorbate 2-phosphate or dehydroascorbic acid makes the cells resistant to the oxidative stress-induced apoptosis.”
“ Dehydroascorbic acid , however, disappears after continued administration of a high dose of ascorbic acid.”
“It seems to indicate that the large dose of ascorbic acid promotes the degradation of dehydroascorbic acid into digekogulonic acid, but further oxidation to oxalic acid does not occur markedly.4.”
“ AsA supplementation significantly increased intracellular levels of AsA, DehAsA , and total VC (i.e., reduced AsA plus oxidized DehAsA) in senescent cells compared with young cells.”
“Finally, we took advantage of our recent findings that DHA potently inhibits AA transport to demonstrate that DHA abolishes all the protective effects of AA , under the same conditions in which the mitochondrial accumulation of the vitamin is prevented without affecting the overall cellular accumulation of the vitamin.”
“The measured concentration of DHA is higher than the concentration of AA in the lenses with the incipient and mature cataract.”
“Direct incubation with AA resulted in increased intracellular ROSs, whereas DHA incubation decreased it.”
“This chemotherapeutic effect was optimally enhanced when AA was added at a concentration of 250 mg/dL. The AA concentrations of 500 mg/dL had a biphasic effect on tumor cell proliferation probably due to back and forth redox reactions between AA and dehydroascorbic acid in a closed system.”
“Renal elimination of ascorbic acid was higher while of dehydroascorbic acid lower vs control.”
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