Possible Interaction: Dehydroascorbic Acid and Quercetin

“ DHA transport activity in GLUT2- and GLUT8-expressing oocytes was inhibited by glucose, fructose, and by the flavonoids phloretin and quercetin.”

“In Jurkat cells, two potent flavonoids (myricetin and quercetin ) competitively inhibited dehydroascorbic acid uptake, and K(i) values were approximately 14 and 15 micromol/L, respectively.”

“We herein report that the flavonoids quercetin and myricetin, while inhibiting dehydroascorbic acid uptake-and thus the erythrocyte ascorbic acid content-effectively stimulate the extracellular reduction of ferricyanide.”

“Simultaneous oxidation and reduction of Hcy and DHA were accelerated extracellularly in the presence of quercetin , an inhibitor of DHA uptake, suggesting that extracellular ascorbic acid concentration increased via blocking DHA uptake by quercetin and reducing extracellular DHA by Hcy.”

“Exposure of rabbit red blood cells to dehydroascorbic acid (DHA) caused a significant decline in glutathione content which was largely prevented by quercetin , whereas it was insensitive to various antioxidants, iron chelators or scavengers of reactive oxygen species.”