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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Dehydroascorbic Acid and Insulin

Research Papers that Mention the Interaction

Preincubation of oocytes for >4 h with insulin (1 micrometer) augmented GLUT4 transport of 2-DG and DHA by up to 5-fold.
Preincubation with insulin (0.67 micrometer) increased transport of each substrate similarly: 7-10-fold for 2-DG and 6-8-fold for DHA.
The Journal of biological chemistry  •  2000  |  View Paper
Insulin increased the intracellular concentration of ascorbate derived from DHAA and also increased the initial rates of uptake of DHAA and 2-deoxyglucose, but not that of ascorbate.
We conclude that insulin and IGF-I stimulate osteoblastic uptake of DHAA through facilitative hexose transporters.
Endocrinology  •  1998  |  View Paper
Dehydroascorbic acid also increased the leakage of insulin from islet tissue.
The Journal of pharmacology and experimental therapeutics  •  1973  |  View Paper