Possible Interaction: Dehydroascorbic Acid and Hydrogen Peroxide

“Enhancement of cellular antioxidant status by pre-incubation of the cells with dehydro-ascorbic acid and lipoic acid, which are reduced intracellularly to ascorbate and dihydrolipoic acid, respectively, afforded protection against caspase-3 activation and apoptosis following addition of H2O2.”

“ DHA also reduced production of reactive oxygen species (ROS) after H2O2 exposure.”

“ DHA significantly increased the glutathione peroxidase (GPx) and glutathione reductase (GR) activities 1 hr after H2O2 exposure.”

“ DHA was found to prevent cell death and reverse mitochondrial dysfunction after exposure to H2O2.”

“Moreover, DHA not only reversed the decrease in the glutathione (GSH) levels, but also significantly enhanced it by stimulating the pentose phosphate pathway (PPP) 15 hr after H2O2 exposure.”

“Due to the reported absence of glutathione peroxidase in insects and the generally low affinity of catalase for hydrogen peroxide, dehydroascorbic acid reductase may play a pivotal role in the elimination of hydrogen peroxide in insects.”

“The results of experiments in which hydrogen peroxide, catalase, or sodium azide were used singly or in combination suggest that the inhibition produced by the ascorbic acid oxidizing system is due, to a considerable extent, to the production of hydrogen peroxide.”

“Furthermore, SS caused substantial decreases in plant physiological-related traits such as …) contents, K+/Na+ ratio, the ratios of reduced ascorbate/dehydroascorbic acid AsA/DHA ) and reduced glutathione/oxidized glutathione (GSH/… contrast, significant increases occurred in leaf hydrogen peroxide , malondialdehyde, electron leakage, proline, the … enzymes' activities, Na+ and NO.”