Possible Interaction: Dehydroascorbic Acid and Homocysteine

“Recently, the author found that dehydroascorbic acid reacts with homocysteine thiolactone converting it to the toxic compound, 3-mercaptopropionaldehyde.”

“In Jurkat and U937 cells, the increasing concentrations of extracellular Hcy suppressed intracellular dehydroascorbic acid uptake, indicating that extracellular reduction of DHA by Hcy leads to decreasing extracellular DHA available for its intracellular uptake.”

“In contrast, Hcy reduced DHA to AA stoichiometrically at concentrations as low as 10 micromol/l.”

“In this paper an account is given … method, based on the two findings that homocysteine rapidly … dehydroascorbic acid at pH 7 0, and that under certain simple conditions 2:6-dichlorophenolindophenol can be used to estimate ascorbic acid in the presence of homocysteine without interference from the latter compound.”