Possible Interaction: Dehydroascorbic Acid and Glucose

“ DHA transport activity in GLUT2- and GLUT8-expressing oocytes was inhibited by glucose , fructose, and by the flavonoids phloretin and quercetin.”

“ DHA transport activity in both GLUT1 and GLUT3 was inhibited by 2-deoxyglucose, d-glucose , and 3-O-methylglucose among other hexoses while fructose and l-glucose showed no inhibition.”

“We conclude that dehydroascorbic acid , but not ascorbic acid, inhibits in vivo brain but not muscle uptake of glucose , suggesting a common carrier system at the level of the blood-brain barrier.”

“Renal brush border or basolateral membrane vesicles pre-incubated with dehydroascorbic acid demonstrate a decrease in initial transport rates of D-glucose and a loss of intravesicular volume.”

“In contrast, glucose competitively inhibited DHA uptake with a Ki of 2.2 mM so that DHA uptake was decreased by glucose even in the physiological range.”

“ D-glucose (> 20 mmol/l) inhibited the DHA uptake, and DHA inhibited D-glucose uptake but not L-alanine uptake.”

“Abstract It has been previously reported that glucose and its structural analogs inhibit dehydroascorbic acid (DHA) transport across the membranes of nonpolar cells, which led to the suggestion that the hexose transporter mediates dehydroascorbic acid transport.”

“ DHA and the D-glucose analogue , 3-O-methyl-D-glucose (3-O-MG) appeared to compete with one another for the transporter.”

“Since glucose inhibited DHAA uptake, this protective mechanism could be impaired in diabetes.”

“DHAA uptake was inhibited partially by glucose added simultaneously with DHAA.”