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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Deferoxamine
supplement:
Vitamin E
Research Papers that Mention the Interaction
“Incubation of C1300 cells with iron also induces an elevation in content of mRNAs coding for the same two proteins that can be blocked by α‐tocopherol and desferrioxamine.”
Changes in Heat Shock Protein 70 and Ubiquitin mRNA Levels in C1300 N2A Mouse Neuroblastoma Cells Following Treatment with Iron“Using the iron chelator deferoxamine (DFO) or the ROS scavenger alpha-tocopherol decreased both autophagy flux and cell death.”
“This is not due simply to a deficiency of vitamin E , and this is profoundly inhibited by deferoxamine.”
“In addition, treatment with DFO attenuated the suppression of the levels of vitamin E and C as well as the inhibition of alkaline phosphatase and glutathione peroxidase activity attributed to K2Cr2O7.”
Protective effect of deferoxamine on chromium(VI)-induced DNA single-strand breaks, cytotoxicity, and lipid peroxidation in primary cultures of rat hepatocytes“Under these experimental conditions, desferrioxamine (15mg/kg administered intravenously before inducing ischaemia), a drug known to limit free radical production, significantly limited the decrease of α-tocopherol to 20.8(6.4)% (0.83(0.08) versus 1.05(0.04) μg/g wet tissue.”
“The results suggested that desferrioxamine prevented the paraquat-induced depletion of vitamin E , but did not improve the mortality due to paraquat.”
“ DFO was also able to improve the activity of α-tocopherol and Trolox in SSO containing DOPC reverse micelles increasing the lag phase from 2 to 11 and 13 days, respectively.”
New insights into the role of iron in the promotion of lipid oxidation in bulk oils containing reverse micelles.
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