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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Deferoxamine
supplement:
Vitamin C
Research Papers that Mention the Interaction
“ Vitamin C , as antioxidant, increases the efficacy of deferoxamine (DFO).”
Role of vitamin C as an adjuvant therapy to different iron chelators in young β‐thalassemia major patients: efficacy and safety in relation to tissue iron overload“ CD-DB exhibited excellent sensitivity and selectivity for the detection of Fe3+ and AA.”
“Combined treatment with N-acetyl-l-cysteine and/or desferrioxamine mesylate attenuated the stimulating effect of ascorbic acid on tyrosinase activation in the cells.”
“Stabilization of ascorbic acid during assay was achieved by addition of desferrioxamine.”
“Moreover, DFO prolonged the generation times of logarithmic growth phase considerably, especially when the reductant AA was present.”
“Cardiac function in eight out of ten patients with thalassemia deteriorated when ascorbic acid was added to desferrioxamine and improved in five of eleven when ascorbate was stopped (15).”
“We aimed to determine if a combination of the antioxidant ascorbic acid and an iron-chelating agent desferrioxamine , which reduces the production of the hydroxyl radical via ferrum-catalyzed reactions, can exert a protective action against reperfusion injury.”
Combined intravenous treatment with ascorbic acid and desferrioxamine to reduce myocardial reperfusion injury in an experimental model resembling the clinical setting of primary PCI.“Even though co‐pretreatment with AA and desferrioxamine could abrogate the aggravating effects of AA on H2O2‐induced cell death at early stages, it could not prevent H2O2‐induced cell death over a 24‐hr period.”
“ Ascorbic acid prevented entirely the beneficial effect of deferoxamine on MDA concentrations in iron-loaded cells, whereas alpha-tocopherol potentiated the effect of deferoxamine.(ABSTRACT TRUNCATED AT 250 WORDS)”
“Growth in the presence of 200Μg/ml deferoxamine combined with 100Μg/ml ascorbic acid was significantly lower than that in control media without additions (p<0.001).”
“However, when ascorbic acid (100Μg/ml) was added to the culture medium, this antimicrobial activity of deferoxamine was significantly increased to on average 75 % of the control value (p<0.05).”
“The results provide evidence that deferoxamine is bacteriostatic due to its capacity to deplete iron which would otherwise be used for bacterial multiplication, and that ascorbic acid enhances this antibacterial property of deferoxamine.”
Inhibition of bacterial multiplication by the iron chelator deferoxamine: Potentiating effect of ascorbic acid
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