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“The iron chelator deferoxamine mesylate DFO ) decreased the iron content in the bone, liver, and spleen, and significantly relieved unloading‐induced bone loss under HyMF reloading.”
“However, as shown earlier with IRP1, both desferrioxamine mesylate and succinyl acetone will inhibit the degradation of IRP2 induced by iron but not that induced by heme.”
“Studies have shown that the degradation of IRP1 that is induced by iron can be inhibited by either desferrioxamine mesylate (an iron chelator) or succinyl acetone (an inhibitor of heme synthesis), whereas the degradation induced by heme cannot.”