Possible Interaction: Deferoxamine and Manganese

“Pretreatment of astrocyte cultures with antioxidants, including vitamin E, … trapping agent PBN, and the iron-chelating agent desferroximine , as well as the nitric oxide synthase inhibitor l-…, all significantly blocked (50-80%) astrocyte swelling caused by manganese , suggesting that oxidative/nitrosative stress is … in the mechanism of such swelling.”

“ DfO also affected Mn‐induced suppression of mitochondrial function as indicated by an additional 16% loss of ATP formation in PC12 cells cotreated with 0.3 mM Mn.”

“ DfO also stimulated Mn‐induced neuronal differentiation by enhancing the phosphorylation of both ERK1 and 2 … also attenuated the increase in caspase 3‐like activity induced by 0.3 mM Mn by approximately 50%, indicating that caspase activation, as reported …, does not contribute to Mn‐induced PC12 cell death.”

“Iron inhibited 54Mn transport with an IC50 of approximately 20 μM. In addition, coincubation of DfO with Mn in PC12 cells resulted in increased expression of both the iron response element‐positive and the iron response element‐negative forms of DMT1.”

“The presence of the siderophore desferrioxamine B (a strong Mn(III)-complexing ligand) effectively decoupled the redox interactions of uranium and manganese to suppress the promotional effect of Mn(II).”