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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Deferoxamine
supplement:
Glutathione
Research Papers that Mention the Interaction
“ DFO partially inhibited the metHb formation and GSH decrease, but it did not protect GR and G6-PD from oxidative damage by tBHP.”
Effect of vitamin C, deferoxamine, quercetin and rutin against tert-butyl hydroperoxide oxidative damage in human erythrocytes“GSH conjugate formation during propargyl alcohol metabolism by microsomal mixed function oxidase in the presence of GSH was also prevented by anti-rat CYP 2E1 or CYP 2E1 inhibitors, (3) cytotoxicity was prevented when lipid peroxidation was inhibited with antioxidants, desferoxamine (ferric chelator) or dithiothreitol.”
Cytochrome P450 2E1 metabolically activates propargyl alcohol: propiolaldehyde-induced hepatocyte cytotoxicity.“ Desferrioxamine , a specific iron chelator, suppressed partly inhibition of cell growth induced by t-BHP and suppressed completely the increase of the cytotoxicity caused by glutathione depletion.”
“ DFO could increase the level of GSH.”
Abnormal Ferroptosis in Myelodysplastic Syndrome“Pretreatment of cells with quercetin, Trolox and DFO inhibited the DNA damage, maintained higher GSH levels and prevented calcium influx significantly.”
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