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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Deferoxamine
supplement:
Ferric Ion
Research Papers that Mention the Interaction
“Importantly, when the DFO was preloaded together with Fe3+ [Fe(III)-DFO], the radiosensitizing effect was lost.”
Radiation Sensitization of Mammalian Cells by Metal Chelators“ Deferoxamine is a potent chelator of ferric iron.”
“The inhibitory effects are reversible and are overcome when ferric iron is present along with deferoxamine in a 2:1 molar ratio.”
“Intracellular iron quantification indicated that, as deferoxamine , exogenous NO significantly decreased intracellular ferric iron levels in tumor cells.”
“This study demonstrates that DFO is a potent S-phase inhibitor of DNA synthesis in human lymphocytes in vitro, and this inhibitory effect of DFO is reversible by adding appropriate amounts of ferric ion.”
“Addition of the iron chelator desferrioxamine to reduce the accumulation of ferric iron from heme by HO-1 resulted in blockade of the aggravated oxygen radical production.”
“As one potential source of ROS formation we identified the lysosomal Fe(2+) pool, since the ferric ion chelator deferoxamin inhibited ROS formation by approximately 15%.”
“The addition of Fe(III) to the dialyzed solution of Apo-ferritin: DFO resulted in the appearance of an orange-red color.”
“ Desferrioxamine prevented death caused by Fe+3 , had no significant effect of the toxicity of Zn+2, and increased that caused by Cu+2.”
“This residual MPP+ production appeared to be iron‐dependent since it was decreased (30 to 50%) by iron chelators, i.e., deferoxamine or phenanthroline, and was enhanced (by approximately 40%) in the presence of ADP‐Fe3+. ”
Iron‐mediated bioactivation of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) in glial cultures“The relatively slow binding of Fe(III) by deferrioxamine also affected lipid peroxidation, an iron-dependent process.”
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