“Accordingly, we explored whether a low dose of the antioxidant sulforaphane SFN ) in combination with the epigenetic drug 5-aza-2’-deoxycytidine (DAC) could slow melanoma cell growth.”
“Methods: Melanoma cell growth characteristics, gene transcription profiles, and histone epigenetic modifications were measured after single and combination treatments with SFN and DAC.”
“Results: We detected melanoma cell growth inhibition and specific changes in gene expression profiles upon combinational treatments with SFN and DAC , while no significant alterations in histone epigenetic modifications were observed.”