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Last Updated: 3 years ago

Possible Interaction: Decitabine and Adrenocorticotropic Hormone

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drug:

Decitabine

supplement:

Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

“Incubation with AZA did not exert an additional stimulatory effect on CRH-stimulated POMC and ACTH.ConclusionsThe present study shows that AZA increases POMC gene expression and ACTH secretion in human pituitary ACTH-secreting tumors.”

“ResultsIncubation with AZA increased constitutive POMC expression and ACTH secretion by human corticotrope adenomas.”

“This can be taken to indicate that mechanisms set into motion by AZA play a role in the regulation of ACTH secretion/POMC expression in tumoral corticotropes and paves the way to further studies in Cushing’s disease.”

AZA-Deoxycytidine stimulates proopiomelanocortin gene expression and ACTH secretion in human pituitary ACTH-secreting tumors

Pituitary • 2013 | View Paper

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