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Discover Supplement-Drug Interactions

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Last Updated: 7 months ago

Possible Interaction: Debrisoquin and Quinine



Research Papers that Mention the Interaction

Although both quinidine and quinine are competitive inhibitors of debrisoquine 4-hydroxylase activity in rat and man, their potency is reversed.
Inhibition of debrisoquine 4-hydroxylase activity by both quinine and quinidine in human and rat liver is competitive.
Biochemical pharmacology  •  1989  |  View Paper
The oxidative routes of methoxyphenamine metabolism which had been previously shown to involve the debrisoquine/sparteine isoenzyme, namely O-demethylation and 5-hydroxylation, were both significantly inhibited by quinine.
Xenobiotica; the fate of foreign compounds in biological systems  •  1991  |  View Paper