Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 months ago

Possible Interaction: Debrisoquin and Quinine

supplement:

Quinine

Research Papers that Mention the Interaction

Although both quinidine and quinine are competitive inhibitors of debrisoquine 4-hydroxylase activity in rat and man, their potency is reversed.
Inhibition of debrisoquine 4-hydroxylase activity by both quinine and quinidine in human and rat liver is competitive.
Biochemical pharmacology  •  1989  |  View Paper
The oxidative routes of methoxyphenamine metabolism which had been previously shown to involve the debrisoquine/sparteine isoenzyme, namely O-demethylation and 5-hydroxylation, were both significantly inhibited by quinine.
Xenobiotica; the fate of foreign compounds in biological systems  •  1991  |  View Paper