Possible Interaction: Deanol and Phosphatidylethanolamine

“ Monomethylethanolamine was found to inhibit ethanolamine uptake, the conversion of ethanolamine to phosphoethanolamine and incorporation of radioactivity into phosphatidylethanolamine.”

“ DMAE reduced embryonic choline uptake and inhibited phosphocholine, PtdCho, phosphatidylethanolamine (PtdEtn), and sphingomyelin synthesis.”

“N‐Monomethyl‐ and N N‐dimethylethanolamine supplements reduced EPG synthesis, prevented its externalization and rescued cells from apoptotic death.”

“Phosphomonomethylethanolamine, phosphodimethylethanolamine and phosphocholine were weak competitive inhibitors of the cytidylyltransferase catalyzed reaction when phosphoethanolamine was used as a substrate, with Ki values of 7.0, 6.8 and 52.9 mM, respectively.”

“The apparent Km for phosphoethanolamine was 0.072 mM. As the number of N-methylated substituents on phosphoethanolamine increased, the apparent Km increased: 0.11 mM for phosphomonomethylethanolamine and 6.8 mM for phosphodimethylethanolamine.”

“The cellular concentration of phosphatidylmonomethylethanolamine was increased 17-fold in response to treatment of hepatocytes with monomethylethanolamine.”

“The presence of either N-methylethanolamine (MME) or N,N-dimethylethanolamine DME ) in the growth medium resulted in significant increase of the corresponding phospholipid, phosphatidyl-N-monomethylethanolamine (PMME) or phosphatidyl-N,N-dimethylethanolamine ( PDME).”

“Following treatment of cells with dimethylaminoethanol , a high proportion of label is incorporated into dimethylethanolamine phosphoglycerides.”