“ Dimethylethanolamine pretreatment antagonized the toxic effect of estradiol 17β‐D‐glucuronide cholestasis, particularly in the canalicular zone, which had a normal structure both 30 and 180 min after estradiol 17β‐D‐glucuronide administration.”
“ Dimethylethanolamine pretreatment significantly counteracted the reduction of membrane fluidity (p < 0.001), the‐cholesterol enrichment and the inhibition of Na+, K+‐ATPase (p < 0.05) promoted by estradiol 17β‐D‐glucuronide administration in all membrane subfractions 30 and 180 min after administration.”
“In conclusion, the intravenous administration of dimethylethanolamine improves the biochemical, biophysical and ultrastructural features of estradiol 17β‐D‐glucuronide cholestasis in the rat. (”
“The estradiol 17β‐D‐glucuronide inhibitory effect on bile flow and biliary lipid secretion was significantly antagonized by dimethylethanolamine pretreatment.”