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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“The expected ACTH response to oCRH was enhanced by the concomitant DP administration (peak level, 10.39 +/- 1.12 vs. 21.37 +/- 3.43 pmol/L in SAL infusion plus oCRH injection vs. DP infusion plus oCRH injection, respectively; P < 0.05).”
“These data confirm that DP potentiates the ACTH response to CRH in humans.”
Effects of ovine corticotropin-releasing hormone injection and desmopressin coadministration on galanin and adrenocorticotropin plasma levels in normal women.“We therefore hypothesized that the combined stimulation of ACTH secretion with CRH plus desmopressin may further improve the diagnostic outcome of this procedure.”
“Studies in patients suffering from melancholic depression indicate a hyper-responsiveness to agonism at the vasopressin receptor type 1B (V(1B)); patients display a heightened ACTH release after challenge with the mixed V(1B)/V(2) (vasopressin receptor type 2) agonist desmopressin in comparison to control subjects.”
“In contrast, a blunted ACTH response to desmopressin was documented throughout the course of vandetanib treatment.”
“Plasma ACTH levels were significantly increased by desmopressin (DDAVP) in 86% of cases with Cushing's disease, especially in microadenomas (90%), while these levels were not affected in normal subjects.”
“Moreover, the combination of serum cortisol suppression >50% after HDDST and an ACTH increase ≥ 35% after the administration of CRH or desmopressin only occurred in CD.”
“ Intravenous desmopressin administration enhanced both circulating concentrations ofACTH and cortisol by 217.36% (peak vs. baseline) and 67% respectively.”
“ ACTH levels in the incubation media were elevated with stimulation by DDAVP , AVP, or CRH.”
“This in vitro study may imply that DDAVP as well as AVP directly stimulates ACTH release from corticotropic adenoma cells.”
“ Desmopressin (DDAVP), an arginine vasopressin analogue, markedly stimulates ACTH secretion in patients with Cushing's disease, in contrast to its minimal effect in normal subjects.”
“While CRH failed to induce an ACTH or cortisol response, intravenous administration of desmopressin led to a 47% increase in serum ACTH and a 42% increase in serum cortisol concentration.”
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