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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ddavp
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“After DDAVP administration there was a significant increase in ACTH (basal: 13.0±1.4 vs peak: 50.5±16.2) and cortisol levels (basal: 572.5±112.7 vs peak: 860.5±102.8.”
GHRP-6 is able to stimulate cortisol and ACTH release in patients with Cushing’s disease: Comparison with DDAVP“A significant ACTH elevation occurred upon DDAVP administration also in normal and obese subjects, but it was much smaller than that observed in patients with CD (P < 0.0001).”
“ DDAVP induced marked ACTH and cortisol rises in CD (P < 0.005 vs. saline, for both ACTH and cortisol) but not in PC.”
“ DDAVP was not able to stimulate ACTH … significantly enhance (P < 0.05) ACTH [area under curve (AUC): 590.0± 104.4 pmol L‐1 120 min‐1 and cortisol (AUC: 28899.… pmol L‐1 120 min‐1, cortisol AUC: 14197.4 ± 2930.0 nmol L‐1 120 min‐1).”
“ DDAVP induced a significant increase in ACTH levels in cultured pituitary adenoma cells, consistent with the in vivo DDAVP test results.”
“ DDAVP stimulation showed significantly higher ACTH peaks in the late recurrence group when compared to the remission group (P< 0.0001).”
“These observations raised the possibility that DDAVP caused an ACTH response, perhaps via the paracrine effects of tumor-derived CRF and Ucn1.”
“Plasma ACTH levels were significantly increased by desmopressin ( DDAVP ) in 86% of cases with Cushing's disease, especially in microadenomas (90%), while these levels were not affected in normal subjects.”
“Multivariate analysis showed that persistence of a positive ACTH response to DDAVP was significantly associated with CD recurrence.”
“After stimulation with CRH or DDAVP an ACTH increase > 35% occurred in 81% of individuals with CD and 16.6% of those with EAS, while an ACTH increase > 50 achieved 100% specificity.”
“Desmopressin DDAVP ), an arginine vasopressin analogue, markedly stimulates ACTH secretion in patients with Cushing's disease, in contrast to its minimal effect in normal subjects.”
“Incubation with DDAVP induced a modest dose-dependent increase in ACTH concentrations which appeared maximal at 10 nM. CRH stimulated ACTH to a greater extent compared with DDAVP and potentiated the effect of DDAVP alone.”
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