Possible Interaction: DCI and Epinephrine

“The observation that dichloroisoproterenol may block the positive inotropic effect of epinephrine , while only slightly reducing the positive inotropic effect of norepinephrine, may be used to differentiate between these two catecholamines.”

“These results are interpreted to indicate that apparent failure of DCI to block adrenaline-induced bigeminy is not due … to antagonize this cardiac action, but is due to a combination of the intrinsic cardiac sympathomimetic activity of DCI with an increase in blood … by the subsequent injection of adrenaline.”

“Both this epinephrine effect and the glucose-induced increase in cyclic AMP are counteracted by the beta-adrenergic inhibitor dichloroisoproterenol.”

“The effect of epinephrine was blocked by single injections of the beta blockers propranolol (10 mg/kg body weight) or dichloroisoproterenol 30 min before the hormone treatment.”

“In all tissues the epinephrine effect was effectively blocked with the beta-adrenergic blocking agents dichloroisoproterenol and propanolol.”

“ Dichloroisoproterenol , a beta-adrenergic blocking agent, competitively inhibits the changes in the epinephrine spectrum while its own spectrum exhibits evidence of binding.”

“ Dichloroisoproterenol , at 1 mg/ml, inhibited the depressing effect of epinephrine at the previously mentioned dose, but had no effect on the depressing effect of progesterone.”

“Pretreatment of rats with dichloroisoproterenol blocked the action of epinephrine upon diaphragm phosphorylase at pH 7.8 and 6.9.”

“Activation produced by a maximal dose of epinephrine (0.1 µg) was blocked by treatment of the hearts with the adrenergic blocking agents, dichloroisoproterenol and nethalide.”

“Atropine, neostigmine, and epinephrine had no significant effect but the acceleration response to stretch was suppressed somewhat by dichloroisoproterenol and augmented by cocaine.”