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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Daunorubicin and Tretinoin

supplement:

Tretinoin

Research Papers that Mention the Interaction

Further, the combination of 1 µM ATRA with different concentrations of Dau demonstrated synergistic effects in HCT116 and KG1a human cells expressing AKR1C3.
Archives of Toxicology  •  2020  |  View Paper
Despite cessation of daunomycin , she demonstrated fluctuating systolic function in relation to ATRA administration.
Journal of pediatric hematology/oncology  •  2010  |  View Paper
We conclude that ATRA and RA exert a slight but clear cytotoxic and apoptotic effect on AML blast cells after 96 h incubation and that retinoids can have an additive or synergistic effects on cell toxicity when added to daunorubicin.
When the retinoids were added to DNR the apoptotic rate increased from 41% with DNR alone to 51% with ATRA (P = 0.01) and to 49% with 9-cis-RA (P = 0.03).
When retinoids were added to DNR the mean decrease in viability was 11 percentage points with ATRA (P = 0.003) and nine percentage points with 9-cis-RA (P = 0.02).
Leukemia research  •  2000  |  View Paper
All-trans retinoic acid (ATRA) increases the sensitivity of AML blast cells to cytosine arabinoside (Ara-C) or daunorubicin DNR ) when ATRA is given after drug.
Leukemia  •  1995  |  View Paper
Cells exposed to ATRA after DNR showed increased toxicity in kinetic experiments.
Leukemia  •  1994  |  View Paper
Induction chemotherapy with cytarabine and daunorubicin was initiated along with all-trans retinoic acid.
Hematology reports  •  2018  |  View Paper
He was treated with all-trans-retinoic acid therapy plus daunorubicin and presented an all-trans-retinoic acid syndrome.
Revista brasileira de hematologia e hemoterapia  •  2011  |  View Paper