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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Daunorubicin and Tretinoin

drug:

Daunorubicin

supplement:

Tretinoin

Research Papers that Mention the Interaction

“Further, the combination of 1 µM ATRA with different concentrations of Dau demonstrated synergistic effects in HCT116 and KG1a human cells expressing AKR1C3.”
Interactions of antileukemic drugs with daunorubicin reductases: could reductases affect the clinical efficacy of daunorubicin chemoregimens?
Archives of Toxicology  •  2020  |  View Paper
“Despite cessation of daunomycin , she demonstrated fluctuating systolic function in relation to ATRA administration.”
Exacerbation of anthracycline-induced early chronic cardiomyopathy with ATRA: role of B-type natriuretic peptide as an indicator of cardiac dysfunction.
Journal of pediatric hematology/oncology  •  2010  |  View Paper
“We conclude that ATRA and RA exert a slight but clear cytotoxic and apoptotic effect on AML blast cells after 96 h incubation and that retinoids can have an additive or synergistic effects on cell toxicity when added to daunorubicin.”
“When the retinoids were added to DNR the apoptotic rate increased from 41% with DNR alone to 51% with ATRA (P = 0.01) and to 49% with 9-cis-RA (P = 0.03).”
“When retinoids were added to DNR the mean decrease in viability was 11 percentage points with ATRA (P = 0.003) and nine percentage points with 9-cis-RA (P = 0.02).”
Effects of retinoids on cell toxicity and apoptosis in leukemic blast cells from patients with non-M3 AML.
Leukemia research  •  2000  |  View Paper
“All-trans retinoic acid (ATRA) increases the sensitivity of AML blast cells to cytosine arabinoside (Ara-C) or daunorubicin DNR ) when ATRA is given after drug.”
Direct evidence for the participation of bcl-2 in the regulation by retinoic acid of the Ara-C sensitivity of leukemic stem cells.
Leukemia  •  1995  |  View Paper
“Cells exposed to ATRA after DNR showed increased toxicity in kinetic experiments.”
Regulation by retinoic acid and hydrocortisone of the anthracycline sensitivity of blast cells of acute myeloblastic leukemia.
Leukemia  •  1994  |  View Paper
“Induction chemotherapy with cytarabine and daunorubicin was initiated along with all-trans retinoic acid.”
Myelodysplasia-related acute myeloid leukemia and acute promyelocytic leukemia: concomitant occurrence of two molecularly distinct diseases
Hematology reports  •  2018  |  View Paper
“He was treated with all-trans-retinoic acid therapy plus daunorubicin and presented an all-trans-retinoic acid syndrome.”
Acute promyelocytic leukemia presenting as an extradural mass
Revista brasileira de hematologia e hemoterapia  •  2011  |  View Paper