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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Daunorubicin
supplement:
Silymarin
Research Papers that Mention the Interaction
“Morin, phloretin, biochanin A, chalcone, and silymarin significantly increased DNM accumulation by greater than 2.5-fold, suggesting they are P-gp inhibitors.”
Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: in vitro and in vivo.“Biochanin-A, genistein, quercetin, chalcone, silymarin , phloretin, morin, and kaempferol, at 100 microM concentrations, all significantly increased the accumulation of both DNM and VBL in Panc-1 cells, with morin increasing DNM and VBL accumulation by 546 +/- 50% (mean +/- SE, n = 9) and 553 +/- 37% (n = 9), respectively.”
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