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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Daunorubicin
supplement:
Quinidine
Research Papers that Mention the Interaction
“In 10 of 11 samples, … multi-drug resistance (Mdr) modulator quinidine altered nuclear daunorubicin ( DNR ) accumulation and whole-cell TPT accumulation by less than 15%, which suggests that Pgp-mediated effects on drug efflux are insufficient to explain the fourfold range of TPT sensitivities in the colony-forming assays.”
Phase I and pharmacodynamic study of the topoisomerase I-inhibitor topotecan in patients with refractory acute leukemia.“Known Pgp inhibitors, such as cyclosporin A, nicardipine, verapamil, quinidine , terfenadine, tamoxifen, and vinblastine were demonstrated to inhibit the Pgp-mediated efflux of daunorubicin.”
“ATP-dependent daunomycin transport was inhibited by cytotoxic drugs (vinblastine, vincristine, and adriamycin) and other drugs, such as verapamil and quinidine , which restore anti-cancer drug sensitivity in resistant cells.”
The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles.
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