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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Daunorubicin
supplement:
Melatonin
Research Papers that Mention the Interaction
“Expert opinion: Our findings clearly demonstrate that melatonin has a protective role in the prevention of chemotherapy-induced nephrotoxicity which may be caused by different chemotherapy agents such as cyclophosphamide, cisplatin, doxorubicin, methotrexate, oxaliplatin, etoposide, and daunorubicin.”
The protective role of melatonin in chemotherapy‐induced nephrotoxicity: a systematic review of non-clinical studies“ Melatonin administered in parallel with daunorubicin decreased the extent of necrosis in tumour cells and reduced the proportion of apoptotic cardiomyocytes.”
Effect of melatonin on cytotoxic effects of daunorubicin on myocardium and on transplantable Morris hepatoma in rats.“Biochemical assays revealed significant decreases in malonyldialdehyde and 4-hydroxyalkenals levels following application of melatonin during either acute doxorubicin (p < 0.05) or subchronic daunorubicin (p < 0.01) intoxication.”
“Biochemical assays revealed significant decreases in MDA and 4‐HDA levels following application of melatonin during subchronic DNR or DOX intoxication.”
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