supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Daunorubicin
supplement:
Glutathione
Research Papers that Mention the Interaction
“…,glutathione plays a role in the detoxification and repair of cellular injury by such diverse agents as …, melphalan, cyclophosphamide, nitrosoureas, 6-thiopurine, 4'-(9-acridinylamino)methanesulfon-m-anisidide, the quinone antibiotics (including Adriamycin, daunorubicin , and mitomycin C), the sesquiterpene lactones (such as …), and other sulfhydryl-reactive diterpenes (like jatrophone).”
Glutathione metabolism as a determinant of therapeutic efficacy: a review.“In contrast, treatment with DNR plus caffeine diminished glutathione levels to a lesser extent than DNR alone.”
“These findings indicated that daunorubicin efficiently affects the GSH antioxidant defense system both in normal and diabetic fibroblasts leading to disturbances in glutathione content as well as in the activity of GSH-related enzymes.”
“Cellular levels of GSH and total glutathione decreased following exposure to DNR.”
“The results provide the first evidence that DNR can induce alterations in the level of glutathione and glutathione‐dependent enzymes in trisomic fibroblasts as compared to normal cells, which may provide additional protection against daunorubicin‐induced oxidative stress in trisomic fibroblasts.”
“Kinetic analysis reveals that GSH in the presence of sodium chloride greatly reduces Km and increases Vmax, for daunomycin.”
“The results demonstrate that glutathione (GSH) enhances transport of daunomycin.”
“There was a statistically significant positive correlation between GSH levels and in vitro sensitivity to daunorubicin (Spearman's rank correlation coefficient rs = 0.38, p < 0.04), melphalan (rs = 0.39, p < 0.04) and prednisolone (rs = 0.48, p < 0.01), but not mitozantrone, etoposide or 6-thioguanine.”
“Chemicals like primaquine, daunorubicin , and methylphenylazoformate trigger the HMS by independently oxidizing both NADPH and GSH.”
“The results indicate that daunorubicin caused a decrease of cytosolic GSH and, after a short lag period, a release of alctate dehydrogenase.”
Effect of daunorubicin on subcellular pools of glutathione in cultured heart cells from neonatal rats.“Bromobenzoic acid and chloramine T (I mM), and daunomycin (60 mu M) induced a slower GSH decrease, down to 30-70% after 60 min.”
Glutathione depletion in the yeast Saccharomyces cerevisiae.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback