“The metabolism of polydatin, geniposide, quercitrin and glycyrrhizin was significantly inhibited by one or … 100 μM around 1 h and 4 h (P<0.05), among which darunavir could strongly reduce ….6% reduction), quercitin (80.6% reduction) and glycyrrhetinic acid (37.9% … high risk of herb-drug interactions (HDI).”