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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Daptomycin
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“The antibacterial action of daptomycin requires its complexation with calcium.”
Clinical Pharmacokinetics of Daptomycin“Our findings also suggested that high levels of Ca++ are needed to ensure the efficacy of daptomycin.”
“The daptomycin-functionalized MBs showed high capture and concentration efficiency for Gram-positive bacteria due to the strong binding between daptomycin and bacterial cell membrane in the presence of Ca2+ ion.”
“SPR and ultrafiltration studies also indicated that physiological concentrations of calcium increase binding of daptomycin and acetyl-daptomycin to HSA and AGP.”
“MIC data showed that the addition of calcium ions to a final concentration of 50 mg/L enhanced the activity of daptomycin generally by eight- to 16-fold.”
“The antibacterial activity of daptomycin was strongly dependent on the calcium concentration of the medium.”
“ Daptomycin demonstrated a stepwise increase in activity corresponding to an increase in the supplemental concentration of calcium.”
In Vitro and In Vivo Activities of Tigecycline (GAR-936), Daptomycin, and Comparative Antimicrobial Agents against Glycopeptide-Intermediate Staphylococcus aureus and Other Resistant Gram-Positive Pathogens“For illustration, we apply this method to daptomycin , an FDA-approved antibiotic that attacks membranes containing phosphatidylglycerol, in the presence of calcium ions.”
Rhombohedral trap for studying molecular oligomerization in membranes: application to daptomycin.“However, in contrast to most linear α-helical peptides, daptomycin binds to lipid bilayers only in the presence of calcium ions , and its activity in vivo is absolutely Ca2+-dependent.”
“In vitro, daptomycin is active against Gram-positive pathogens at low concentrations but its antibiotic activity depends critically on the presence of calcium ions.”
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